Rheumatoid arthritis is a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition also can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels.
The inflammation associated with rheumatoid arthritis is what can damage other parts of the body as well. While new types of medications have improved treatment options dramatically, severe rheumatoid arthritis can still cause physical disabilities.
Signs and symptoms of rheumatoid arthritis may include:
Tender, warm, swollen joints
Joint stiffness that is usually worse in the mornings and after inactivity
Fatigue, fever and weight loss
Which Kinds of cells are used in Rheumatoid Arthritis and how are they obtained?
Adult stem cells are obtained from itc bank from donor tissue or autologous transplant, which is harvested from the patient’s own adipose tissue and it takes 21 days to culture, differentiate and administer the adult stem cells to the patient.
How can Stem Cells Help Rheumatoid Arthritis?
Currently, RA is treated with immune suppressive agents such as steroids, methothrexate, cyclosporine, gold, and more recently infliximab (Remicade). Despite inducing temporary improvement, these approaches possess long-term adverse effects due to non-specific inhibition of immune responses. Additionally, current treatments do not address the issue of damage that has already occurred to the joints or extra-articular tissues.
Because Rheumatoid Arthritis complications include inflammation and tissue damage adult stem cells may target inflamed areas of the body and produce anti-inflammatory agents. Stem cells have the ability to produce Regulatory T cells, a type of immune cell whose responsibility is to regulate the immune system while maintaining tolerance to self-antigens. By differentiating into these types of healthy cells there is a possibility that adult mesenchymal cells will be able to address the complications caused by Rheumatoid Arthritis.
How are Mesenchymal Stem Cells (MSC) administered in Stroke?
A typical treatment is as following; stem cells are administered by a license physician.
Medical evaluation and blood testing (Day 1)
Hyperbaric chamber (Day 2)
1 intrathecal injection and intravenous injection of Stem Cells (Day 3)
Djouad, F., Bouffi, C., Ghannam, S., Noël, D., & Jorgensen, C. (2009). Mesenchymal stem cells: innovative therapeutic tools for rheumatic diseases. Nat Rev Rheumatol, 5(7), 392-399. http://dx.doi.org/10.1038/nrrheum.2009.104
Treatment of collagen-induced arthritis using immune modulatory properties of human mesenchymal stem cells. (2015). Cell Transplantation. http://dx.doi.org/10.3727/096368915x687949
Ichim, T., Harman, R., Min, W., Minev, B., Solano, F., & Rodriguez, J. et al. (2010). Autologous stromal vascular fraction cells: A tool for facilitating tolerance in rheumatic disease. Cellular Immunology, 264(1), 7-17. http://dx.doi.org/10.1016/j.cellimm.2010.04.002